Development of casein-based nanoencapsulation systems for delivery of epigallocatechin gallate and folic acid

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Abstract

In this work, binding characteristics of two hydrophilic nutraceutical models, namely epigallocatechin gallate (EGCG) and folic acid (FA), to sodium caseinate were studied by fluorimetry technique. EGCG-loaded casein molecules were then converted to either re-combined casein micelles (r-CMs) or casein nanoparticles (CNPs). Binding stoichiometry of EGCG and FA was 0.81 and 1.02, respectively. As determined by DLS technique, the average particle size of r-CMs prepared at 0.5% concentration was 66.2 nm. Thermal treatment (74°C, 20 s) had significant (p < 0.05) influence on the particle size of nanocarriers, but not nutraceutical loading. The average size of CNPs was larger than that of r-CMs. The encapsulation efficiency (EE) of EGCG was 85%, and its ejection from the nanocarrier was less than 3% over 21 days. Alkaline conditions resulted in higher release of EGCG than acidic conditions. r-CMs were more effective than CNPs during the protection of EGCG against heat-induced degradation. TEM micrographs confirmed the formation of r-CMs.

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Malekhosseini, P., Alami, M., Khomeiri, M., Esteghlal, S., Nekoei, A. R., & Hosseini, S. M. H. (2019). Development of casein-based nanoencapsulation systems for delivery of epigallocatechin gallate and folic acid. Food Science and Nutrition, 7(2), 519–527. https://doi.org/10.1002/fsn3.827

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