Efficacy of microneedling in treatment of acne scars

Abstract

INTERVENTION: Co2 fractional laser, 4 times, 3 weeks apart Intervention 1: Microneedeling, 4 times, 3 weeks apart. Intervention 2: Microneedeling and topical platelet‐rich plasma (PRP) , 4 times, 3 weeks apart. Intervention 3: Co2 fractional laser, 4 times, 3 weeks apart. Microneedeling and topical platelet‐rich plasma (PRP) , 4 times, 3 weeks apart Microneedeling, 4 times, 3 weeks apart Treatment ‐ Other CONDITION: Acne vulgaris Condition 1: acne. Condition 2: Atrophic scar. ; Acne vulgaris ; Scar conditions and fibrosis of skin Scar conditions and fibrosis of skin PRIMARY OUTCOME: Patient satisfaction rate of response to treatment. Timepoint: Three weeks after each session and 3 months after the last session. Method of measurement: Questionnaire(percentage). Response to treatment. Timepoint: Three weeks after each session and 3 months after the last session. Method of measurement: By a physician, according to the measure of the severity of acne scar goodman and high quality photography by visioface device. INCLUSION CRITERIA: INCLUSION CRITERIA: Patient with atrophic acne scars; Ages 20 to 50 years old Exclusion criteria: Active acne; Patients with platelet dysfunction, sever thrombocytopenia (less than 50,000); Any hemodynamic instability or chronic diseases (such as diabetes, chronic infections, blood dyscrasia ); Local inflammatory skin disorder or active herpes infection at the site of the procedure; Taking an anticoagulant or NSAID within 48 hours before the procedure; Corticosteroid injection at the treatment site during 1 month; Use of systemic corticosteroids within 2 weeks; Fever or recent illness; Cancer, particularly bone or blood; Hemoglobin level less than 10 grams per deciliter