Chinese medicines for preventing and treating radiation-induced pulmonary injury: A review of 2007-2017

Abstract

Thoracic radiotherapy is a mainstay of the treatment for lung, esophageal, and breast cancers. Radiation-induced pulmonary injury (RIPI) is a common side-effect of thoracic radiotherapy, which may limit the radiotherapy dose and compromise the treatment results. However, the current strategies for RIPI are not satisfactory and may induce other side-effects. Chinese medicines (CMs) have been used for more than a thousand years to treat a wide range of diseases, including lung disorders. In this review, we screened the literature from 2007 to 2017 in different online databases, including China National Knowledge Infrastructure (CNKI), Chongqing VIP, Wanfang and PubMed, summarized the effectiveness of CMs in preventing and treating RIPI, explored the most frequently used drugs, and aimed to provide insights into potential CMs for RIPI. Altogether, CMs attenuated the risk of RIPI with an occurrence rate of 11.37% vs. 27.78% (P 0.001) compared with the control groups. We also found that CMs (alone and combined with western medical treatment) for treating RIPI exerted a higher efficacy rate than that of the control groups (78.33% vs. 28.09%, P 0.001). In the screened literature, 38 CMs were used for t he prevention and treatment of RIPI. The top five most frequently used CMs were Astragali Radix (with a frequency of 8.47%), Ophiopogonis Radix (with a frequency of 6.78 %), Glycyrrhizae Radix et Rhizome (with a frequency of 5.08%), Paeoniae Radix Rubra (with a frequency of 5.08%) and Prunellae Spica (with a frequency of 5.08 %). However, further high-quality investigations in CM source, pharmacological effects and underlying mechanisms, toxicological aspects and ethical issues are warranted. Taken together, CMs might have a potential role in RIPI prevention and treatment and still have a long way to investigate. (with a frequency of pharmacological effects ethical issues are warranted. CMs might have a potential role in RIPI prevention and treatment CMs might have a potential role in RIPI prevention and treatment way to investigate.