MicroRNA-Mediated Regulation of HMGB1 in Human Hepatocellular Carcinoma

6Citations
Citations of this article
5Readers
Mendeley users who have this article in their library.

Abstract

High-mobility group box 1 (HMGB1) is a potential therapeutic target and novel biomarker in a variety of malignant tumors, including hepatocellular carcinoma (HCC). More recently, a number of microRNAs (miRNAs) are identified as a class of regulators for broad control of HMGB1-mediated biological actions in eukaryotic cells. In this review article we will describe representative miRNAs involved in regulating the HMGB1 signaling pathways in HCC cell lines and/or animal models. We also propose the possible mechanisms underlying the miRNA/HMGB1 axis and discuss the future clinical significance of miRNAs targeting HMGB1 molecule for HCC therapy.

Cite

CITATION STYLE

APA

Yan, J., Ying, S., & Cai, X. (2018). MicroRNA-Mediated Regulation of HMGB1 in Human Hepatocellular Carcinoma. BioMed Research International. Hindawi Limited. https://doi.org/10.1155/2018/2754941

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free