Plasma kinetics and urine profile of ethyl glucosides after oral administration in the rat

Abstract

In this in vivo study, the time course of plasma concentration and the urinary excretion of ethyl α-D-glucoside (α-EG) and ethyl α-D-glucoside (α-EG) were investigated in rats after a single oral dose of 4 mmol/kg body weight. Maximal plasma concentrations of both α-EG and β-EG (EGs) reached approximately 3 mM at 1 h after oral administration and then decreased rapidly. Approximately 80% of EGs administered were excreted into the urine during the first 6 h. Within 24 h, cumulative urinary α-EG and β-EG excretions were estimated to be 87:2 ± 7:9% and 85:4 ± 5:0%, respectively. Traces of both EGs were detected in plasma and urine 24 h after oral ingestion. The results of this study indicate that almost all of both EGs was rapidly absorbed into the blood stream and easily excreted into the urine after oral administration, and that a small amount of them remained in the rat body 24 h after administration.