Preparation and Evaluation of Fast Dissolving Buccal Thin Films of Bufotenin

Abstract

The present investigation was undertaken with the objective of formulating Bufotenin for rapid dissolution of drug and absorption which may produce the rapid onset of action and also to improve the bioavailability of the drug. The fast dissolving strips were prepared by solvent casting method with the selection of HPMC E5, E15, K15, and Microcrystalline Cellulose (MCC), Polyvinyl Alcohol (PVA) as polymers and glycerol as plasticizer. Prepared films were carried out for in vitro evaluation tests such as film thickness, folding endurance, and content uniformity, estimation of moisture content, tensile strength, elongation, disintegration studies and dissolution studies. As per the official limits, film has to release the maximum amount of drug within a minute and it was satisfied by the formulations F1, F4, F7 and F8. It could be concluded from the results that the fast dissolving oral thin film can be a potential dosage form for pediatric and geriatric patients showing effective and faster drug release.