Self-sampling and HPV testing or ordinary Pap-smear in women not regularly attending screening: A randomised study

Abstract

Results:The participation rate was 39% (771 out of 2000) in the self-sampling group and 9% (188 out of 2060) in the conventional cytology (P=0.001). The number of histological CIN2-3 alterations detected was 0.4% (8 out of 2000) among women offered self-sampling of vaginal fluid and 0.07% (3 out of 4060) in women offered Pap-smears. The odds ratio (O=R) for offering self-sampling and HPV testing instead of Pap-smear screening for detection of CIN2-3 was OR5.42 (95% CI: 1.30-31.8). Conclusion: Offering self-sampling of vaginal fluid followed by a high-risk HPV test was considerably more effective for detection of histological CIN2-3 lesions in comparison with offering Pap-test in a midwife reception in women not regularly attending organised screening. © 2011 Cancer Research UK All rights reserved.