An electrochemical sensor for determination of ceftazidime based on poly (crystal violet) doped platinum nanoparticles modified electrode

Abstract

An electrochemical sensor for determination of ceftazidime (CFD) was fabricated by polymerizing crystal violet (PCV) and platinum nanoparticles (nanoPt) on a glassy carbon electrode (GCE). The nanoPt/PCV composite film exhibited excellent catalytic performance toward CFD. On this modified electrode, the CFD had an irreversible oxidation peak at 0.8 V with a dramatically amplified current value. The electrochemical behaviors of CFD and the conditions that may affect these behaviors were investigated detailedly on the nanoPt/PCV/GCE. Under the optimized conditions, the sensor showed a wide linear range over the concentration of CFD from 0.25 to 10 μM. The detection limit was 0.01 μM. The sensor can be applied for detecting the content of CFD in meat samples with good selectivity and stability. The recovery was between 97.8% and 103%.