Abstract
Alkylation of a central gap of three phosphorodithioate linkages into a dodecathymidine methylphosphonate with methylacylthioethyl iodide (Me-SATE-I) yielded the corresponding neutral oligonucleotide. Upon incubation of the resulting non ionic prooligonucleotide in cell extracts, the bioreversible Me-SATE masking groups were selectively removed by carboxyesterases present in the milieu.
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CITATION STYLE
Tosquellas, G., Barber, I., Morvan, F., Rayner, B., & Imbach, J. L. (1996). The prooligonucleotide approach. III: Synthesis and bioreversibility of a chimeric phosphorodithioate prooligonucleotide. Bioorganic and Medicinal Chemistry Letters, 6(4), 457–462. https://doi.org/10.1016/0960-894X(96)00051-0
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