Relationship between biometry, fovea, and choroidal thickness in Nigerian children with myopia

Abstract

Background: Understanding the relationship between biometric and structural changes in childhood myopia is necessary to effectively manage myopia progression. Aim: To determine the relationship between ocular biometry, fovea and sub-fovea choroidal thickness in school-aged children with myopia of Nigerian descent. Setting: Abuja, Nigeria. Methods: This study involved 189 children (117 girls and 72 boys), and myopia was defined as cycloplegic spherical equivalent refraction (SER) of ≤ −0.50 D. Keratometry values, biometry data, fovea and sub-foveal choroidal thickness (SFChT) values were obtained from medical records retrospectively and analysed. Results: The median age was 13 years (interquartile range [IQR]: 5). The median SER, fovea and SFChTs were −2.63 D (IQR: 3.38), 249 μm (IQR: 118) and 225 μm (IQR: 341), respectively. Male children had flatter corneas, thicker fovea and thinner SFChT compared to female children. The vitreous chamber and axial length were longer and sub-fovea choroid was thinner in children with high myopia. There was a weak but significant positive correlation between myopia and sub-fovea choroidal thickness (r = 0.270 respectively, P < 0.01). A moderate negative correlation was found between myopia and vitreous chamber depth (r = −0.536, P < 0.001), and a strong negative correlation was found between myopia and axial length (r = −0.706, P < 0.001). Conclusion: Myopia in school-aged Nigerian children is associated with sub-fovea choroidal thinning, increased vitreous chamber depth and axial elongation. Contribution: This study provides data on the relationship between ocular biometry, fovea and sub-foveal choroidal thickness in school-aged Nigerian children with myopia.