Biomechanical Study of the Development of Long Bones: Finite Element Structure Synthesis of the Human Second Proximal Phalanx Under Growth Conditions

Abstract

Torsional loads are a possible mechanical explanation for the architecture of long bone. Finite element structure synthesis (FESS) has previously successfully been used as a deductive technique using Wolff's Law by applying expected loads to an unspecific homogeneous solid and eliminating stress free parts to verify muscle forces. The extended approach presented in this article includes further mechanobiological rules to model the development from a cartilage model to a finger bone. In contrast to former computational models, simulation of processes leading to both external growth and internal differentiation are included. Combined axial and torsional loads synthesize a complete human secondary proximal phalanx model comparable to form and internal structure to that observed in vivo. While the computational model is very sensitive to initial alterations of loads, changes after growth have a minor effect as observed in animal models. Predictions of cartilage growth and ossification during FESS showed significant similarities to ontogeny indicating the importance of mechanical factors for the morphogenesis of bone during growth. Anat Rec, 302:1389–1398, 2019. © 2018 Wiley Periodicals, Inc.