Age-matched normal values and topographic maps for regional cerebral blood flow measurements by xe-133 inhalation

Abstract

The relationship between normal aging and regional cerebral blood flow (rCBF) computed as initial slope index (ISI) by Fourier method was investigated in 105 right-handed healthy volunteers (132 measurements) by Xe-133 inhalation method, and age-matched normal values were calculated. Mean brain ISI values showed significant negative correlation with advancing age (r = -0.70, p < 0.001), and the regression line and its 95% confidence interval was Y = -0.32 (X-19) + 63.5 ± 11.2(19 ≦ x ≦ 80). Regional ISI values also showed significant negative correlations for the entire brain (p < 0.001). The regional reductions of ISI values with advancing age were significantly greater in the regional distribution of the middle cerebral arteries bilaterally, compared with regions in the distribution of the other arteries (p< 0.05). Therefore, measured rCBF values for patients must be compared to age-matched normal values for mean hemispheric and each region examined. Two kinds of topographic maps, brain map showing rCBF compared to age-matched normal values and showing hemispheric differences were made by dividing patient's values by the 95% confidence limits for age-matched normal values and displaying laterally index calculated as follows, respectively. © 1984 American Heart Association, Inc.