Formulation Development of Celecoxib Loaded Microsponges using Eudragit and Ethyl Cellulose

Abstract

Background: Microsponge is a class of dosage form containing porous nature containing drug that is targeted to achieve sustained action for prolong period. Microsponge based delivery system results in drug localization on skin surface and in epidermis without moving in systemic circulation to higher extent. Methods: Present study aims to formulate the microsponge containing celecoxib by quasi emulsification solvent diffusion method. Prepared formulations were evaluated for particle size, % entrapment efficiency, production yield, surface morphology, etc. Results: Formulation F1 and E2 were considered as optimized formulation having drug loading 91±4.2 % and 91±3.1 % respectively. FTIR spectroscopy analysis indicated the chemically stable, crystalline nature of the drug in these microsponges. Small change in crystallinity of pure drug was observed in XRD study. SEM study shows good microsponge surface appearance with pores on surfaces. Average particle size of optimized