Evaluation the Risk of Preeclampsia in Periodontal Patients Compared With Healthy Individuals: A Meta-Analysis Study

Abstract

Periodontal disease (PD) is a common oral condition that has been suggested to have potential adverse effects on pregnancy outcomes, including preeclampsia. This meta-analysis aims to investigate the association between PD and preeclampsia. A comprehensive search of relevant studies was conducted, and data were analyzed using a random effects model with the Mantel–Haenszel method to estimate the pooled odds ratio (OR) and assess heterogeneity. The results revealed that women with PD had a significantly higher risk of developing preeclampsia (OR = 1.20, 95% CI: 1.01–1.42). Heterogeneity among the studies was minimal (I2 = 43.8%), despite the chi-squared test indicating some heterogeneity (χ2 = 48.03, d.f. = 27, p = 0.008). These findings underscore the importance of incorporating periodontal care into prenatal care routines to mitigate the risk of adverse pregnancy outcomes.