Peptide-Induced Hydrogelation with Ordered Metal-Organic Framework Nanoparticles Generating Reactive Oxygen Species for Integrated Wound Repair

Abstract

Hydrogels, with their high water content and flexible nature, are a promising class of medical dressings for combating bacterial wound infections. However, their development has been hindered by low sterilization efficiency. Here, this issue is addressed by designing a peptide hydrogel that assembles ordered metal-organic framework (MOF) nanoparticles with photocatalytic bactericidal activity. Specifically, a short peptide, Nap-Gly-Phe-Phe-His (Nap-GFFH), is used to induce the assembly of zinc-imidazolate MOF (ZIF-8) into a hydrogel (NHZ gel). This innovative structure integrates three key features: 1) ZIF-8 nanoparticles are encapsulated within the hydrogel, overcoming their inherent brittleness, insolubility, and limited moldability; 2) the ordered ZIF-8 structure enhances charge transfer, enabling efficient generation of reactive oxygen species (ROS); and 3) ZIF-8 simultaneously improves the photocatalytic bactericidal efficiency and mechanical properties of the hydrogel. The NHZ gel demonstrates remarkable antibacterial performance, achieving >99.9% and 99.99% inactivation of Escherichia coli and Staphylococcus aureus, respectively, within 15 min of simulated solar radiation. Additionally, the NHZ gel exhibits excellent biocompatibility, water retention, and exudate absorption, highlighting its broad potential for wound healing.