S(-) Bupivacaine (S(-)BVC) and Lidocaine (LDC) are widely used local anesthetics (LA). Hydroxypropyl β-cyclodextrin (HP-β-CD) is used as a drug-carrier system. The aim of this work was to characterize inclusion complexes between LA and HP-β-CD. The affinity constants determined at different pHs show favourable complexation. The release kinetics experiments showed that S(-)BVC and LDC changed the released profiles in the presence of HP-β-CD. Nuclear magnetic resonance experiments gave information about the interaction between LA and the cyclodextrin cavity. This study focused on the physicochemical characterization of drug-delivery formulations that come out as potentially new therapeutic options for pain treatment.
CITATION STYLE
Moraes, C. M., Abrami, P., Gonçalves, M. M., Filho, N. A., Fernandes, S. A., De Paula, E., & Fraceto, L. F. (2007). Preparação e caracterização físico- química de complexos de inclusão entre anestésicos locais e hidroxipropil-β-ciclodextrina. Quimica Nova, 30(4), 777–784. https://doi.org/10.1590/S0100-40422007000400005
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