Antibiotic management of infections with multidrug-resistant organisms (MDRO) represents a complex clinical challenge. We report here the first patient with a severe MDRO infection managed with assistance of a novel "real-time" 3-day high-throughput screen (HTS) that allowed screening of 9 drugs in 14 combinations in 2,304 total samplings. Identified synergies were used to modify patient therapy with the goal of reducing drug-induced toxicity. The desired clinical outcome was achieved on the HTS-informed therapeutic regimen, supporting the utility of HTS technology to expand standard antimicrobial susceptibility testing.
CITATION STYLE
Sun, W., Hesse, S., Xu, M., Childs, R. W., Zheng, W., & Williamson, P. R. (2018). “Real-Time” high-throughput drug and synergy testing for multidrug-resistant bacterial infection: A case report. Frontiers in Medicine, 5(SEP). https://doi.org/10.3389/fmed.2018.00267
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