Alveolar bone repair with strontiumcontaining nanostructured carbonated hydroxyapatite

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Abstract

Objective: This study aimed to evaluate bone repair in rat dental sockets after implanting nanostructured carbonated hydroxyapatite/sodium alginate (CHA) and nanostructured carbonated hydroxyapatite/sodium alginate containing 5% strontium microspheres (SrCHA) as bone substitute materials. Methods: Twenty male Wistar rats were randomly divided into two experimental groups: CHA and SrCHA (n=5/period/group). After one and 6 weeks of extraction of the right maxillary central incisor and biomaterial implantation, 5 µm bone blocks were obtained for histomorphometric evaluation. The parameters evaluated were remaining biomaterial, loose connective tissue and newly formed bone in a standard area. Statistical analysis was performed by Mann-Withney and and Wilcoxon tests at 95% level of significance. Results: The histomorphometric results showed that the microspheres showed similar fragmentation and bio-absorbation (p>0.05). We observed the formation of new bones in both groups during the same experimental periods; however, the new bone formation differed significantly between the weeks 1 and 6 (p=0.0039) in both groups. Conclusion: The CHA and SrCHA biomaterials were biocompatible, osteoconductive and bioabsorbable, indicating their great potential for clinical use as bone substitutes.

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Carmo, A. B. X. do, Sartoretto, S. C., Alves, A. T. N. N., Granjeiro, J. M., Miguel, F. B., Calasans-Mala, J., & Calasans-Mala, M. D. (2018). Alveolar bone repair with strontiumcontaining nanostructured carbonated hydroxyapatite. Journal of Applied Oral Science, 26. https://doi.org/10.1590/1678-7757-2017-0084

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