The impact of transcriptional cycling on gene regulation

Abstract

Research of the past decade showed that transcriptional regulation could be a highly dynamic and cyclical process. Many transcription factors and their co-regulators cyclically associate with a periodicity of 30-75 min with regulatory chromatin regions resulting in dynamically changing chromatin marks and cyclical activities of RNA polymerase II in mRNA synthesis. © 2010 Landes Bioscience.