Studies on combination of antibiotics (V)

Abstract

In vitro combined activity of cephalothin (CET) and amikacin (AMK), cefazolin (CEZ) and dibekacin (DKB), cefmetazole (CMZ) and DKB against K. pneumoniae PCI 602 was examined. Bactericidal activity against K. pneumoniae PCI 602 was enhanced by combination of cephems. (CEPs) and aminoglycosides (AGs). When bacilli were treated for two hours with CEPs (1/2 MIC) plus AGs (1/2MIC), the viable cell count decreased markedly and the colony-forming unit was found to be 1/1,000 of the initial inoculum. Morphological changes of K. pneumoniae PCI 602 were observed by electron microscopy, when bacilli were treated with CEZ and DKB alone and in combination. Combination If CEZ (1/2 MIC) and DKB (1/2 MIC) caused marked destruction of the bacilli. © 1982, Japanese Society of Chemotherapy. All rights reserved.