Formulation and Evaluation of Fast Dissolving Buccal Film of Curcumin as Promising Route of Buccal Delivery

Abstract

The present work is mainly focused on preparing fast dissolving buccal films of Curcumin solid dispersion, since Curcumin is a poorly soluble drug. The main aim of this is to provide quick onset of action, improved bioavailability and also to increase the patient convenience of administration. The rate of dissolution can be increased by incorporating the solid dispersed drug into film which is prepared by HPMC-K100 as polymers, glycerin as a plasticizer, sorbitol as an antioxidant, Tween & Span as a non-ionic surfactant. The films were evaluated for their physiochemical parameters like disintegration time, surface pH, thickness, weight, percent moisture absorption, folding endurance, drug content and stability testing. The invention is to produce mucoadhesive buccal patches, which heals the lesion/ injury with replacing patches.