Gombapyrones, new α-pyrone metabolites produced by Streptomyces griseoruber Acta 3662

Abstract

Gombapyrones A-D, new members of the α-pyrone family of secondary metabolites, were produced by Streptomyces griseoruber Acta 3662, which was isolated from bamboo tree rhizosphere. The strain was characterized by its morphological and chemotaxonomical features and by 16S rDNA sequencing as S. griseobuber. The gombapyrone structures were determined by mass spectrometry and by NMR experiments, and were found to have an inhibitory activity against protein tyrosine phosphatase 1B and glycogen synthase kinase 3Β. © 2009 Japan Antibiotics Research Association.