Nanoparticles with in vivo anticancer activity from polymer prodrug amphiphiles prepared by living radical polymerization

Abstract

Magic rubber bullets: Novel anticancer nanoparticles made of well-defined polymer-drug conjugate amphiphiles are prepared by the controlled growth of a hydrophobic polyisoprene chain from a drug macroinitiator by using nitroxide-mediated polymerization (NMP; see picture). The resulting conjugates self-assembled into nanoparticles exhibiting high drug payloads and significant anticancer activities both in vitro and in vivo. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.