Abstract
Leukocyte mRNA expression and plasma protein, metabolite, and lipid levels were measured in 102 COVID-19 and 26 non-COVID-19 patient samples. 219 diverse biomolecules were strongly associated with COVID-19 status and severity and pointed to dysregulation of processes related to lipid transport, blood coagulation, acute phase response, endotheliopathy, and neutrophil degranulation in this disease.
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Overmyer, K. A., Shishkova, E., Miller, I. J., Balnis, J., Bernstein, M. N., Peters-Clarke, T. M., … Jaitovich, A. (2021). Large-Scale Multi-omic Analysis of COVID-19 Severity. Cell Systems, 12(1), 23-40.e7. https://doi.org/10.1016/j.cels.2020.10.003
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