Antibacterial and antifungal activity of scabronine G and H in vitro

Abstract

Two interesting cyathane-type diterpenoids, scabronines G and H, isolated from the fruiting bodies of the basidiomycete, Sarcodon scabrosus (L.: Fr.) Karst, were tested against the bacteria, Staphylococcus aureus, Bacillus thuringiensis, Escherichia coli, Bacillus megaterium and Bacillus subtilis. Both scabronine G and H showed promising activity in vitro against the five bacteria tested at 1 mg/ml and 100 μg/ml. The degree of antibacterial activity of both scabronine G and H was almost the same as streptomycin. Scabronines G and H were also tested against the pathogenic fungi, Gibberella zeae (Schwein.) Petch, Sclerotinia sclerotiorum (Lib.) de Bary, Fusarium moniliforme Sheldon, Fusarium oxysporum Schltdl., Fusarium oxysporum f. sp. vasinfectum, and Fusarium oxysporum f. sp. capsicum. Both scabronines G and H showed promising activity in vitro against G. zeae, S. sclerotiorum, F. moniliforme, F. oxysporum at 1 mg/ml and showed weak activity in vitro against F. oxysporum f. sp. vasinfectum and F. oxysporum f. sp. capsicum at the same concentration. © 2010 Mycological Society of China.