Recent advances in metal-, organo-, and biocatalyzed one-pot tandem reactions under environmentally responsible conditions

Abstract

Because of their handedness and wide scope, transition-metal-, organo-, and biocatalyzed tandem processes have become routine and highly sought-after methodologies because they dramatically increase synthetic efficiency, while decreasing the number of laboratory operations, the quantities of chemicals and solvents used, producing in a simpler way highly complex organic molecules with the desired selectivity. In this current opinion, recent examples of the use of metal-, organo-, and biocatalyzed tandem processes run under environmentally responsible conditions (e.g., use of water, bio-based solvents, or without additional solvents) are showcased, highlighting practical and valuable aspects.