Isolation and characterization of a new antitumor antibiotic OS-3256-b from streptomyces candidus var. azaticus

Abstract

OS-3256-B is a new member of azaamino acid substances obtained from the culture filtrate of Streptomyces candidus var. azaticus which was reported in a previous paper. This antibiotic is remarkably effective against experimental murine tumors such as S-180 tumor and leukemia L-1210. The antibiotic is also obtainable from alazopeptin by chemical transformation. © 1974, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.