Modelling cell-cell collision and adhesion with the filament based lamellipodium model

Abstract

We extend the live-cell motility Filament Based Lamellipodium Model (FBLM) to incorporate the forces exerted on the lamellipodium of the cells due to cell-cell collision and cadherinВ induced cell-cell adhesion. We take into account the nature of these forces via physical and biological constraints and modelling assumptions. We investigate the effect these new components have in the migration and morphology of the cells through particular experiments. We exhibit moreover the similarities between our simulated cells and HeLa cancer cells.