Epigallocatechin gallate Cream Formulation For Anti Aging

Abstract

Premature aging is a big problem for a woman. Early aging can cause a feeling of lack of confidence. Signsof premature aging include the appearance of black spots, fine lines appear, pores appear to be enlarged,dull, the face feels rough, the eyes change shape, facial skin relaxes and even skin discoloration can occur.Many factors can trigger premature aging, namely excessive sun exposure, sleeping position, consumption ofunhealthy foods and drinks, the skin lacks rest because it always wears makeup, stressful, sleep deprivationand genetics. Premature aging can be prevented by using anti-aging cosmetics. One of the substances thatcan be used as an anti-aging is epigallocatechin gallate. Epigallocatechin gallate is a compound fromnatural ingredients that has antioxidant activity. The antioxidant activity of epigallocatechin gallate ishigher than that of vitamin C and vitamin E. Epigallocatechin gallate is a high antioxidant (100 timesvitamin C or 25 times vitamin E). This study aims to formulate anti-aging creams with active ingredientsepigallocatechin gallate with different concentrations of cream bases so as to obtain anti-aging creams withoptimal physical characteristics. Cream base is the main excipient material in forming the consistency of acream preparation. In this study the cream base used is lexemul CS-20 where the cream base contains acombination of 2 cream bases namely cetearyl alcohol and ceteareth-20). Researchers hope that using onlyone ingredient can provide optimal results. In this study, we want to know the effect of base creamconcentration on the physical characteristics of epigallocatechin gallate cream. The base creamconcentrations used are 10%, 15% and 20%. The results showed that the F1, F2 and F3 formulas wereorganoleptically the same white and homogeneous, only that the F1 formula was slightly runny. Based onthe results of the pH test on the formula F1, F2 and F3 give no significant difference. All formulas are creams with oil-in-water type emulsions. The higher concentration of cream base gives a higher viscosityvalue, conversely the higher the concentration of cream base the smaller the spread of cream. Based on thestability test with the centrifugation method F1 formula looks unstable because the preparation separatesinto 2 phases, whereas in formulas F2 and F3, the preparation does not separate (stable).