A simple and efficient protocol for the oxidation of trifluoromethyl, mono- and difluoromethyl sulfides to the corresponding sulfoxides without over-oxidation to sulfones, using TFPAA prepared in situ from trifluoroacetic acid and 15% H2O2 aqueous solution was developed. The methodology is suitable for a wide range of aromatic and aliphatic substrates in milligram and multigram scales.
CITATION STYLE
Sokolenko, L. V., Orlova, R. K., Filatov, A. A., Yagupolskii, Y. L., Magnier, E., Pégot, B., & Diter, P. (2019). General, practical and selective oxidation protocol for CF3s into CF3S(O) group. Molecules, 24(7). https://doi.org/10.3390/molecules24071249
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