Toksisitas Oral Subakut Filtrat Buah Luwingan (Ficus hispida L.f.) pada Tikus Riul[Rattus norvegicus (Berkenhout, 1769)] Wistar Jantan

Abstract

Hairy Fig trees flourish in tropic regions, bearing abundant fruits all year round. Ethnobiological studies state that the fruits have been used as food or traditional medicine. However, some references reported that consuming the fruits cause dizziness, nausea, and vomiting. Therefore, we conducted this experiment to provide information regarding the toxicity and safety of consuming the fruits. Procedure following OECD Oral toxicity study of rodent was performed following the guide line of testing chemical No. 407. Repeated oral toxicity study was conducted for 28 days with some modification whithout changing the guideline. Nine male rats were selected as model to complement the toxicity study on male rats that had been done previously. Pure filtrate of young or ripe fruits were administered orally 1 mL/individual/day for consecutive 28 days. Feeding behavior and fecal conditions were recorded for qualitative data. Quantitative data consisted of body weight, core temperature, hematology profile, and evaluation of liver, heart, and renal functions were collected on day 0, 7, 14 and 28. Results showed that oral administration of young or ripe hairy fig fruits filtrate on male Wistar rats did not cause death or sublethal conditions as manifestation of clinical signs of toxicity. Both filtrates did not reduce appetite and affected the digestive system, as well as did not harm the general health indicated by all parameter’s values were maintained within normal range. It can be concluded that no-observed-adverse-effect- level (NOAEL) of hairy fig fruits filtrate was found in a concentration of 100%