Coexistence of seizure with Wilson's disease: a systematic review

Abstract

Wilson's disease is a rare autosomal recessive disease with worldwide prevalence of about 30 individuals per million population. It is caused by mutation in the ATP7B gene, resulting in malfunctioning ATP7B protein with subsequent copper deposition in brain, kidneys, cornea and other organs.1 Although early treatment of copper overload can be effective, long-term de-coppering therapy can result in epileptic seizures. Dr Ibrahim investigates the types, frequency and causes of seizures occurring concomitantly in patients with Wilson's disease.