Viral MRI contrast agents: Coordination of Gd by native virions and attachment of Gd complexes by azide-alkyne cycloaddition

Duane E. Prasuhn; Robert M. Yeh; Andre Obenaus; Marianne Manchester; M. G. Finn

Journal Article

Viral MRI contrast agents: Coordination of Gd by native virions and attachment of Gd complexes by azide-alkyne cycloaddition

Chemical Communications (2007) (12) 1269-1271

DOI: 10.1039/b615084e

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Abstract

Icosahedral virus particles decorated with a Gd(DOTA) analogue by Cu-mediated azide-alkyne cycloaddition (CuAAC) and/or with Gd3+ ions by coordination to the viral nucleoprotein show increased T1 relaxivity relative to free Gd(DOTA) complexes in solution. © The Royal Society of Chemistry.

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Prasuhn, D. E., Yeh, R. M., Obenaus, A., Manchester, M., & Finn, M. G. (2007). Viral MRI contrast agents: Coordination of Gd by native virions and attachment of Gd complexes by azide-alkyne cycloaddition. Chemical Communications, (12), 1269–1271. https://doi.org/10.1039/b615084e

Viral MRI contrast agents: Coordination of Gd by native virions and attachment of Gd complexes by azide-alkyne cycloaddition

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