Interactions between the neuromuscular blocking drug org nc45 and some anaesthetic, analgesic and antimicrobial agents

Abstract

The effects of some ansestheucs and other agents used in anaesthetic practice on the neuromuscular blocking activity of cumulative doses of Org NC45 have been studied in cats anaesthetized with chioralose. As expected from studies with other neuromuscular blocking drugs, both inhalation and i.v. anaesthencs reduced the doses of Org NC 45 required for neuromuscular blockade. An apparently specific potentiating interaction between Org NC45 and metromdazole was observed. © 1981 Macmillian Publishers Ltd.