TP53 Mutations and Survival in Squamous-Cell Carcinoma of the Head and Neck

  • Poeta M
  • Manola J
  • Goldwasser M
  • et al.
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Abstract

The abrogation of function of the tumor-suppressor protein p53 as a result of mutation of its gene, TP53, is one of the most common genetic alterations in cancer cells. We evaluated TP53 mutations and survival in patients with squamous-cell carcinoma of the head and neck.

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Poeta, M. L., Manola, J., Goldwasser, M. A., Forastiere, A., Benoit, N., Califano, J. A., … Koch, W. M. (2007). TP53 Mutations and Survival in Squamous-Cell Carcinoma of the Head and Neck. New England Journal of Medicine, 357(25), 2552–2561. https://doi.org/10.1056/nejmoa073770

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