Macrosphelide, a novel inhibitor of cell-cell adhesion molecule II. Physicochemical properties and structural elucidation

Abstract

New anticell-adherence compounds, macrosphelides A and B, were isolated from the fermentation broth of Microsphaeropsis sp. FO-5050, and their structures were elucidated by spectroscopic methods and by chemical transformations. Macrosphelides A (M.W. 342, C16H22O8) and B (M.W. 340, C16H20O8) with three esters in their molecules were classified as 16-membered macrocyclic compounds. Macrosphelide B was found to be a corresponding oxidative product of macrosphelide A at the C-14 position.