Quantitative Solid-State NMR Spectroscopy (qSSNMR) in Pharmaceutical Analysis

Abstract

Pharmaceutical analysis is essential to drug development and quality assurance, ensuring that products meet stringent safety and efficacy standards. Quantitative solid-state NMR (qSSNMR) has become a key technique, enabling precise quantification and characterization of solid drug formulations. This mini-review highlights the evolution of qSSNMR, focusing on improvements in detection limits, resolution, and high-throughput capabilities. This review explores technical advancements and applications for analyzing complex pharmaceutical mixtures. While challenges remain for widespread adoption, efforts in automation, user-friendly software, and collaboration aim to address these.