Merkel Cell Carcinoma, Version 1.2024 Featured Updates to the NCCN Guidelines

Abstract

The NCCN Guidelines for Merkel Cell Carcinoma (MCC) provide recommendations for diagnostic workup, clinical stage, and treatment options for patients. The panel meets annually to discuss updates to the guidelines based on comments fromexpert review frompanelmembers, institutional review, as well as submissions from within NCCN and external organizations. TheseNCCNGuidelines Insights focus on the introduction of a new page for locally advanced disease in the setting of clinical node negative status, entitled "Clinical N0 Disease, Locally Advanced MCC."This new algorithmpage addresses locally advanced disease, and the panel clarifies the meaning behind the term "nonsurgical"by further defining locally advanced disease. In addition, the guideline includes the management of in-transit disease and updates to the systemic therapy options.