Engagement of the T cell antigen receptor (TCR) triggers signaling pathways that lead to T cell selection, differentiation and clonal expansion. Superimposed onto the biochemical network is a spatial organization that describes individual receptor molecules, dimers, oligomers and higher order structures. Here we discuss recent findings and new concepts that may regulate TCR organization in naïve and memory T cells. A key question that has emerged is how antigen-TCR interactions encode spatial information to direct T cell activation and differentiation. Single molecule super-resolution microscopy may become an important tool in decoding receptor organization at the molecular level. © 2012 Rossy, Williamson, Benzing and Gaus.
CITATION STYLE
Rossy, J., Williamson, D. J., Benzing, C., & Gaus, K. (2012). The integration of signaling and the spatial organization of the T cell synapse. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2012.00352
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