Pharmacological study of weight losing of liraglutide loaded within layered double hydroxide carrier

Abstract

The anti-diabetic drug liraglutide was loaded within LDH nanoparticles using the Fe+3, Al+3, Fe+2 and Ni+2 ions, the preparation of LDH was carried out via the titration of 2M of NaOH with trivalent and divalent ions in presence 0.5M HCl, the prepared compounds of liraglutide with LDH were tasted with selective groups of rats. The compounds were characterized with Fourier transform infra-red (FTIR), X-ray diffraction (XRD), Atomic force microscopy (AFM), Zeta potential and Scanning electron microscopy (SEM). The animals that injected with weekly dose of the prepared compounds shows the weight reduction comparative with that of the animals injected daily dose of pure liraglutide.