Aryl Chalcones as Efficient Precursors for Deriving Oxazine: Solvent-Free Synthesis and Antimicrobial Activities of some Oxazine-2-amines

Abstract

A series of some oxazine derivatives has been synthesised by fly-ash:H2SO4 catalyzed solvent-free cyclization of aryl chalcones and urea under microwave irradiation. The yields of the oxazines were more than 85%. The synthesised oxazines were characterized by their physical constants, analytical and spectroscopic data. The antimicrobial activities of these oxazines have been studied using Bauer-Kirby method.