Exercise can promote coronary collateral development without improving perfusion of ischemic myocardium

Abstract

We studied the effect of exercise training on the coronary collaterals that developed in response to gradual coronary occlusion in dogs. After their proximal left circumflex coronary artery occlusion, 33 dogs were randomly assigned to exercise or sedentary groups. Coronary collateral function was evaluated 5 weeks or 8 weeks later. The exercised dogs developed better epicardial collateral connection to the occluded left circumflex as judged by higher retrograde blood flow from the distal left circumflex and lower pressure drop across the collaterals. No difference in collaterals was apparent angiographically. Microsphere data indicated that exercise dogs were not better protected against tachycardia-provoked subendocardial ischemia in the myocardium supplied by the collaterals.