Simplified synthesis of isotopically labeled 5,5-dimethyl-pyrroline N-oxide

Abstract

5,5-Dimethylpyrroline N-oxide ( 15N) and 5,5-di(trideuteromethyl) pyrroline N-oxide were synthesized from the respective isotopically labeled 2-nitropropane analogs obtained from the reaction of sodium nitrate with 2-halopropanes. This facile, straightforward process allows synthesizing isotopically labeled DMPO analogs in a 4-step reaction without special equipment.