Hand grip strength and biomarkers in patients with chronic kidney disease on hemodialysis

Abstract

Background: Chronic kidney disease (CKD) is associated with impairment of physical capacity as a consequence of systemic involvement mainly related to the presence of anemia, sarcopenia, malnutrition, and inactivity, resulting in decreased functional capacity. Measurement of hand grip strength (HGS) is a useful marker of nutritional status, reflecting lean muscle mass, assessing functional status, and predicting prognosis and survival in end-stage renal disease (ESRD). Purpose: To determine the relationship between hand grip strength and serological biomarkers in patients with CKD on hemodialysis. Methodology: a study with a quantitative approach, cross-sectional design, and correlational scope. Registration of the information on the REDCap (Research Electronic Data Capture) platform, data collection was between April and November 2022. HGS measured with a Biometrics G200 dynamometer, and serological data was analyzed: hemoglobin, triglycerides, potassium, total cholesterol, and albumin. Results: statistically significant differences were found between the sexes in terms of hemoglobin, triglycerides, total cholesterol, and hand grip strength levels. There is a directly proportional relationship between hand grip strength with HB (Rho=0.31; p=<0.00), albumin (Rho=0.42; p=<0.00), and potassium (Rho=031; p=<0.00). Conclusions: The theoretical basis for this article can be conclusive regarding the relationship between frailty and sarcopenia, with some important biomarkers in this population, which may allow the analysis of decreased strength as an influencing factor in the patient’s quality of life. The theory supports a direct relationship between pathophysiological factors and frailty, which translates into decreased functional strength in patients with CKD.