RUNX1 in T-ALL: Tumor suppressive or oncogenic?

Abstract

In this issue of Blood, Choi et al demonstrated an oncogenic role of RUNX1 in T-cell acute lymphoblastic leukemia (T-ALL),1 which is in marked contrast to its tumor-suppressive role identified earlier in T-ALL, acute myeloid leukemia (AML), and myelodysplastic syndrome (MDS).