Quality Control Testing of Chloramphenicol Eye Drops

Abstract

Background and aims. Choramphenicol is one of important therapeutic options for bacterial conjunctivitis. Its eye drop formulation must possess standards of good quality and sterility. The drug is very sensitive to light and temperature and must be stored between 2 and 8 ᵒ C. This study included testing two of the marketed eye-drops formulations of chloramphenicol of two different origins to ensure quality and efficacy of the drugs. Methods. The test methodology followed same pharmacopeial tests to evaluate both physical and chemical aspects of the drugs tested. Identification tests and assay were carried out. Results. Both products passed the identification tests however, there were different findings and the product from Pakistani company failed to comply with BP limits for the pH range and assay. Conclusion. It is of great importance to check on some drugs to see if affected during transport and distribution by testing samples collected randomly from pharmacies.