Oxidized LDL as A Biomarker in Metabolic Syndrome

Abstract

Objective: To study the correlation of lipids and lipoprotein indices with special reference to oxidized LDL in study subjects. Material and Methods: Study comprised of total 124 subjects. 104 symptomatic cases either sex age between 20-80 years were recruited, of which, 10 were type-2 diabetes mellitus(Type-2DM), 63 were with metabolic syndrome (MS), and 31 were type-2 diabetes mellitus with hypertension (Type-2DM+HT). Total 20, age and sex matched normal healthy subjects were recruited and served as control group for the present study. Results: Comparing the mean OxLDL of four groups (Type-2DM, MS, Type-2DM+HT and normal), by one way ANOVA showed significantly (p<0.001) differences among the groups. Further, Bonferroni test showed that the mean OxLDL rose significantly (p<0.001) in cases (Type-2DM, MS and Type-2DM+HT) groups as compared to normal group but no differences were observed among the cases. Conlusion: It is concluded that OxLDL may serves as better predictive biomarker in metabolic syndrome individuals.