Abstract
Using mutations in the human Melanocortin-4 Receptor (MC4R), Brouwers et al. identify receptor trafficking and endocytosis, coupling to Gαs/β-arrestins, and homodimerization as mechanisms involved in the regulation of body weight that may be targeted for weight loss therapy.
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Brouwers, B., de Oliveira, E. M., Marti-Solano, M., Monteiro, F. B. F., Laurin, S. A., Keogh, J. M., … Mokrosiński, J. (2021). Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation. Cell Reports, 34(12). https://doi.org/10.1016/j.celrep.2021.108862
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