Synthesis of a novel chalcone derivative from myristicin for skin cancer preventive activity

Abstract

Chalcone with the presence of methoxy and two oxygenated substituents is predicted to have good anticancer activity. Therefore a novel chalcone derivative 3 from myristicin was synthesized through three synthesis steps 1, 2, characterized by GC-Ms, IR, and1H-NMR. Molecular target screening of skin cancer from the myristicin derivatives are Heat Shock Protein 90 (HSP90A), Prostaglandin Synthase 2 (PTGS2), and Dihydroorotate Dehydrogenase (DHODH). Molecular docking performed using AutoDock-Tools 1.5.6. The results showed that HSP90A, PTGS2, and DHODH were predicted as potential macromolecule targets with good interactions with myristicin derivatives for skin cancer therapy. Chalcone derivatives from myristicin are predicted as potent compounds against skin cancer molecular protein targets by docking molecular studies.