In vitro release studies on multiple and simple emulsions of α-tocopherol with Pistacia leaves

Abstract

α-Tocopherol is the most effective lipid soluble natural antioxidant and free-radical scavenger. The present study aimed to evaluate the performance of the extracts of Pistacia lentiscus, P. lentiscus var. chia and P. terebinthus leaves as additives on in vitro release of α-tocopherol. The α-tocopherol content of Pistacia extracts were determined and the release was investigated from w/o/w multiple emulsion, w/o and o/w simple emulsions through cellulose acetate and cellulose nitrate membranes by using HPLC-UV method. As significant increase in the extent of α-tocopherol release was observed with the addition of Pistacia extracts in all emulsions. They could be suggested as suitable additives in α-tocopherol containing formulations. © Österreichische Apotheker-Verlagsgesellschaft m. b. H.